The importance of radiation quality for optimisation in radiology
CJ Martin, PhD, FIPEM, FioP
Health Physics, Gartnavel Royal Hospital, Glasgow, Scotland
Abstract
Selection of the appropriate radiation quality is
an important aspect of optimisation for every clinical imaging task in
radiology, since it affects both image quality and patient dose. Spreadsheet
calculations of attenuation and absorption have been applied to basic imaging
tasks to provide an assessment of imaging performance for a selection of
phosphors used in radiology systems. Contrast, which is an important component
of image quality affected by radiation quality, has been assessed in terms of
the contrast to noise ratio (CNR) for a variety of X-ray beams. Both CNR and
patient dose fall with tube potential, and selection of the best option is a
compromise that will provide an adequate level of image quality with as low a
radiation dose as practicable. It is important that systems are set up to match
the response of the imaging phosphor, as there are significant differences
between phosphors. For example, the sensitivity of barium fluorohalides used in
computed radiography declines at higher tube potentials, whereas that of
gadolinium oxysulphide used in rare earth screens increases. Addition of 0.2 mm
copper filters, which can reduce patient entrance surface dose by 50%, may be
advantageous for many applications in radiography and fluoroscopy. The
disadvantage of adding copper is that tube output levels have to be increased.
Application of simple calculations of the type employed here could prove useful
for investigating and assessing the implications of potential changes in X-ray
beam quality prior to implementation of new techniques. © 2007 Biomedical
Imaging and Intervention Journal. All rights reserved.
Introduction
The most important choices in optimisation of radiology
exposures relate to the amount of radiation to be used and the distribution of
photon energies in the X-ray beam or the radiation quality. The latter
influences the balance between image quality and dose to the patient because of
the manner in which interactions between X-ray photons and tissue vary with
photon energy. Radiation quality is determined by the X-ray tube potential
selected and the filtration of the X-ray beam. Metal filters are fitted to
X-ray tubes to attenuate lower energy photons that are unlikely to reach the
image receptor. A filter equivalent to at least 2.5 mm of aluminium is
incorporated as standard in medical X-ray tubes and is required by national
guidance [1, 2], but additional copper filters may be inserted. Once installed,
the filters in radiographic units are seldom altered, but in more complex units
used for interventional radiology and cardiology, filters can be added for
selected procedures. This may be the choice of the operator or may be
determined automatically based on the attenuation of the part of the body being
imaged and the procedure programme selected. Tube potential, on the other hand,
is selected by the operator for every imaging task either directly or in
pre-set programmes. In fluoroscopic procedures, the manner in which the tube
potential and current are increased to maintain the dose rate at the image
intensifier, is determined by programmes linked to different types of
examination.
The interaction of X-ray photons with tissue will be
reviewed briefly to highlight the implications for X-ray imaging. The processes
that are important in the formation of a radiological image are the
photoelectric absorption and Compton scattering [3, 4, 5]. The probability of
photoelectric interaction increases rapidly with the atomic number of atoms
present in the tissue, so it produces good contrast between tissue structures
with different elemental compositions. This is demonstrated by the differences
in photoelectric mass attenuation coefficients for bone and soft tissue (Figure
1) [6]. Compton scattering is an inelastic process, in which the X-ray photon
loses some of its energy and is deflected from its original path, creating a
background of random events or noise that degrades the image. The mass
attenuation coefficient for Compton scattering is almost independent of tissue
composition for diagnostic X-rays, and the probability of interaction depends
solely on tissue density. Thus, the contribution of Compton scattering to image
contrast is much less than that of the photoelectric effect. For diagnostic
X-rays, the number of photons interacting through the photoelectric effect
decreases rapidly with photon energy, while the probability of Compton scattering is largely independent of energy (Figure 1). As a result, the proportion
of photons interacting via the photoelectric effect changes with the energy
spectrum of the X-ray beam, and this affects both image contrast and patient
dose [5, 7].
X-ray beams used for medical imaging contain photons with
a wide range of energies. The proportion of interactions via the photoelectric
effect is higher for X-ray beams containing more low-energy photons (30 keV-50
keV), and so the image contrast is better. However, the greater absorption of
energy through the photoelectric effect reduces the proportion of X-rays that
is transmitted through the body. As a result, a higher radiation intensity is
required and this increases the radiation dose to the patient. More photons in
higher energy X-ray beams will penetrate through the body and reach the image
receptor. This will tend to give a lower radiation dose, but the image contrast
will be poorer. Thus, the choice of photon energy characteristics or radiation
quality of an X-ray beam is a crucial component of optimisation in radiology.
Optimisation requires the consideration of both radiation
dose and image quality. Radiation dose in this paper is quantified in terms of
three quantities; the air kerma incident on the patient, which is proportional
to measurements of the dose-area product [8]; the entrance surface dose (ESD),
which is the dose to the skin and includes backscattered radiation [8]; and the
effective dose [9], which is a quantity computed from simulations that can be
estimated from the ESD or dose-area product [8, 10, 11]. Image quality is more
difficult to quantify than radiation dose. Detailed imaging performance
requires consideration of the ability of the imaging device to reproduce
details in terms of the modulation transfer function, and the ability to
visualise details and the background noise within the image in terms of the detective
quantum efficiency or noise equivalent quanta [12, 13]. The most important
factor that changes with radiation quality is image contrast and the influence
of this on the image can be described in terms of the contrast to noise ratio
(CNR). This relates to the contrast or signal difference between larger objects
and the image background, but does not incorporate information on resolution.
Nevertheless, it is a measure of the aspects in imaging performance, which
relate to the choice of X-ray exposure factors. In this study, theoretical
simulations have been applied, in order to demonstrate how radiation quality
affects both the quality of a radiological image and the radiation dose to the
patient. Values for the CNR have been calculated using tissue attenuation properties
inserted into a simple attenuation model described and validated in an earlier
paper [14]. These have been used to assess how different factors, which alter
the X-ray beam quality, influence the imaging performance of radiological
imaging systems.
Methods
Simple spreadsheet calculations have been performed using
data sets for X-ray spectra, filter, phantom and tissue mass attenuation
coefficients, and phosphor mass energy absorption coefficients at 1 keV
intervals over the range 1 keV to 150 keV [6, 15]. These have been used to
predict the responses of radiological imaging systems with different tube
potentials and filter options.
The energy absorbed in an image receptor A(E) at
each photon energy E has been derived from the equation:
(1)
where µen(E)/r p, rp
and dp are the mass energy absorption co-efficient, density
and thickness, respectively, of the image receptor phosphor. Data for the
phosphors that have been used in the calculations are listed in Table 1. The
caesium iodide phosphor layer can be thicker because the needle-shaped crystals
can be aligned so that the needle axes are perpendicular to the image plate,
limiting the lateral spread of light that would otherwise degrade the
resolution. The thickness of layers of other phosphors need to be limited to
about 200 μm in order to maintain resolution.
The phosphor sensitivities for X-ray beams of different
radiation qualities have been calculated by multiplying equation (1) by the
respective number of photons or fluence within each energy interval in the
X-ray beam (y(E)). The results
for all photon energies up to the maximum (Emax) for each tube potential
(kV) have been summed to give a measure of the energy absorbed by the
image receptor at a particular tube potential ξ(kV).
(2)
where yr(E)
is the fluence for photons of energy E incident on the image receptor.
The quantity ξ(kV) has been used as a measure of the image
responses of different receptors, such as optical density for film, and light
output or signal for digital radiography systems. In order to compare the
relative sensitivities R(kV) of image phosphors to X-ray beams with
different radiation qualities, each result has been divided by the total photon
fluence incident on the image receptor.
(3)
Photon fluences have been calculated from data on
X-ray spectra generated at different tube potentials and adjusted for
attenuation in different filter materials and tissues using tabulated mass
attenuation coefficients [15, 6]. The fluence of X-ray photons of energy E
transmitted through a phantom or patient, and incident on the image receptor yr(E) has been represented
by:-
(4)
where yi(E)
is the X-ray photon fluence incident on the patient, and µt(E), rt and dt
are attenuation co-efficient, density and thickness, respectively, for each
layer of tissue or phantom material t through which the X-ray beam has
passed. The thicknesses of the various tissues within different parts of the
chest, abdomen and pelvis traversed by the X-ray beam were measured from
sections of adult computed tomography scans, assuming a focus to image receptor
distance of 110 cm (Table 2). It was assumed that 80% of the volume taken up by
the lung was occupied by air [16].
Values for the air kerma incident on the patient or the
image receptor were calculated by substituting yi(E) or yr(E)
respectively for y(E) in the
equation:
(5)
where men/r is the mass energy absorption
coefficient for air. The incident air kerma is used in several examples to show
how dose varies with tube potential. Values for patient ESDs for particular
examinations were calculated for different X-ray beam spectra by multiplying
the incident air kerma by backscatter factors for the appropriate projections
[10], and effective doses for a reference patient were derived using tabulated
conversion coefficients [8, 11].
The difference in contrast C(E) resulting from
photons of energy E for a feature with linear attenuation coefficient µ2(E)
in an object with attenuation µ1(E) has been derived from the
equation:-
(6)
where I2(E) and I1(E)
are the photon intensities transmitted through the feature and the surrounding
area, respectively, and d is the thickness of the feature. The factor
µ(E).d
in equation (6) was represented by the product of the linear attenuation
coefficient for muscle and a small depth of muscle tissue, rather than the
differences in tissue attenuation coefficients. Equation (6) has been
multiplied by the photon fluence for each energy interval yr(E) and the result summed
over the relevant X-ray spectra in order to derive values for the image
contrast. The signal can be expressed in terms of the mean number of X-ray
photons detected (N) by each image pixel, area a. Pixel
dimensions of 0.14 mm were employed in the calculations.
(7)
The contrast relates to the difference in the mean number
of X-ray photons transmitted through the feature (DN).
(8)
Since the standard deviation, which describes the
fluctuations in quantum noise, is equal to the square root of the number of
photons detected (ÖN), the CNR
for an ideal image receptor including only quantum noise can be expressed as:-
(9)
This has been multiplied by the relative sensitivity R(kV)
(equation 3) to compare imaging performance for different phosphors. This
approach assumes that quantum noise makes the dominant contribution to image
noise, which will normally be the case for most radiological images. Results
were calculated relative to the response at 80 kVp for each spectrum and the
tube currents, and so the numbers of photons within the X-ray beams at each
tube potential were multiplied by an adjustment factor [F(kV) = ξ(80) /
ξ(kV)] to equalise the responses of the detectors for each tube
potential. For chest radiography in which different tissues are portrayed in
the same image, CNRs have been calculated for different regions based on
similar levels of air kerma transmitted through the lung fields in order to
mimic exposures terminated by an automatic exposure control (AEC) device.
CNR is proportional to vN, whereas patient dose is
proportional to N, so a figure of merit that is independent of the
number of photons, and relates solely to differences in the radiation quality,
can be defined as the quotient of CNR2, divided by the system
dose.
(10)
Values calculated for the ESD were substituted into
equation (10) as the system dose. The simulations reported in this paper relate
to the transmitted primary beam and do not take account of scattered radiation
reaching the image receptor. Nevertheless, they demonstrate basic relationships
between radiation quality, image quality and dose that can be applied in
optimisation of radiological systems.
Results
Phosphor sensitivity
The main factors, which affect the radiation quality of an
X-ray beam, are the tube potential and the beam filtration. However, there is
another factor that influences the quality of the image obtained with different
X-ray spectra and that is the variation in the sensitivity of the detector with
photon energy. Phosphors or photodiodes are used to convert X-ray energy into
light or an electrical signal that can be recorded. Phosphors that are
considered in this paper are listed in Table 1, together with the properties
used in the calculations and the areas of application. The variations in
sensitivities of these phosphors, based on the absorbed energy derived from
equation (1), are shown in Figure 2. Relative sensitivities of the same
phosphors to X-ray beams corresponding to different tube potentials have been
calculated from equation (3) and are portrayed in Figure 3.
Caesium iodide imaging plates are substantially more
sensitive than the other systems available, because of the thicker phosphor
layers used, so that it should be possible to set these up with image receptor
doses of 1.6 mGy to 2.0 mGy, equivalent to a 600 speed index
screen/film combination. This is the approach that has been followed in hospitals
in the West of Scotland. The sensitivity of gadolinium oxysulphide indirect
digital radiography (IDR) systems is similar to that for the screen/film
equivalent (400 speed index, 2.5-2.8 mGy
detector dose), although the greater dynamic range may be used to achieve some
reduction in dose. Direct comparison of the imaging performance for barium
fluorohalides, the computed radiography (CR) phosphor, with gadolinium
oxysulphide, used in screen/film systems, might suggest that the radiation
exposure would need to be 30% to 40% higher to compensate for the lower
sensitivity (Figure 3). However, this is offset by the better contrast and
dynamic range of digital systems, which should allow satisfactory imaging with
a CR system employing a similar dose level to that for a 400 speed index rare
earth screen/film system at 80 kVp (2.5-3.0 mGy
at the image plate). This approach has been adopted in the West of Scotland
with satisfactory results. Selenium, which is a semiconductor photodiode
sensitive to X-rays, is employed for direct digital radiography. Selenium
performs well at lower photon energies and is used for digital mammography. A
higher resolution can be achieved because an intermediate light emitting
phosphor is not required.
An important factor that should be taken into
consideration is the effect of the difference in the way the sensitivity varies
with tube potential. The sensitivity of gadolinium oxysulphide used in rare
earth film screen combinations and some IDR systems increases with tube
potential by 10% between 60 kVp and 100 kVp, whereas that of barium
fluorohalides, which are used in most CR systems, decline by about 17% over
this range. This has important implications for the setting up of automatic
exposure control (AEC) devices when an X-ray department is converting from
screen/film to CR [17]. If an AEC system set up for a rare earth screen/film
combination is used for CR systems, it is likely that either images taken with
higher tube potentials will have a higher noise level, or exposures at lower
tube potentials will be unnecessarily high.
Tube potential
The potential applied to the X-ray tube determines both
the maximum photon energy and the proportion of higher energy photons. The
optimum potential will depend on the part of the body being imaged, the size of
the patient, the type of information required, and the response of the image
receptor. Figure 4 shows how the incident air kerma declines with tube
potential for imaging conditions adjusted to achieve a similar system response
at each tube potential. Results are plotted for several different phosphors for
imaging a 20 cm thick abdomen, to show how differences in sensitivity depicted
in Figure 3 translate into patient dose. Results are also shown for thicker
tissue sections for a rare earth phosphor to demonstrate the increase in dose
required for imaging. The change in contrast with the thickness of tissue being
imaged for the transmitted beam is small, if the tube potential is kept
constant, but the level of scatter from the thicker tissue layers will increase
and so the CNR will decline. In addition, the tube potential will normally be
increased in order to maintain the dose to the patient at an acceptable level
and this will further reduce image contrast. In order to obtain radiographs with
a similar ESD for a section of the abdomen that was 250 mm thick, compared to
one that was 200 mm thick, the tube potential would need to be increased by
about 10 kVp. If the same tube potential was used for both, the ESD to achieve
the same image receptor signal would be three times higher for the thicker
abdomen. A compromise will normally be chosen, where a slightly higher tube
potential is used, accepting some reduction in image contrast, but avoiding the
ESD being too high.
The CNR describes the components of image quality that are
affected by the radiation quality and is used here as a measure of imaging
performance. The change in CNR to achieve a constant value for the energy
absorbed in a phosphor as the tube potential is raised has been calculated using
equation (9). Relative changes in the CNR and dose quantities with tube
potential are shown in Figure 5. X-ray beams, which contain a greater
proportion of photons with energies between 30 keV and 50 keV, give better
image contrast (Figure 1), and as a result the CNR gradually declines as the
tube potential is raised. However, more of the photons are absorbed in the
body, so it is necessary to use a larger radiation intensity in order for
sufficient photons to be transmitted through the body to form an image.
Relative values for the ESD and effective dose are shown in Figure 5 for an
antero-posterior (AP) abdominal radiograph. The effective dose does not fall
with tube potential as rapidly as the ESD because lower energy photons make a
larger contribution to the absorbed dose at the skin surface for tissues deeper
within the body.
The imaging requirements for chest radiography differ from
those for other parts of the body because of the larger difference in
attenuation between the lungs and the mediastinum. Chest radiography has been
simulated under imaging conditions in which the air kerma incident on the image
receptor behind the lung remained constant. This was to represent the
termination of the exposure using AEC chambers positioned behind the lungs.
Although the air kerma incident on the patient across the whole field is
similar, the air kerma incident on the image receptor is much lower in the
region of the heart and spine. The dependence of ESD and effective dose on tube
potential for a postero-anterior (PA) chest radiograph are shown in Figure 6.
Comparatively, the decrease in effective dose with tube potential is lower for
PA chest radiographs than for an AP abdomen (Figure 5). This is because the
sensitive organs lie closer to the anterior surface of the body, which is
adjacent to the image receptor, and the change in dose to deeper tissues with
tube potential is lower as the beam has been attenuated by overlying tissues.
Values for the CNR have been calculated using different
thicknesses of tissue feature in different parts of the image (Table 2) in
order to enable the relationships to be viewed on a similar scale. Results are
shown for a phosphor used in rare earth screen/film combinations (Figure 7a)
and a CR system (Figure 7b). These give an indication of how the visualisation
of tissue structure varies in different parts of the chest image and how this
changes with tube potential. There are differences in imaging performance with
the different phosphors, resulting from the variation in sensitivity portrayed
in Figure 3. The CNR for the lung tends to decline with tube potential, but for
the gadolinium oxysulphide phosphor, it levels off between 60 kVp and 90 kVp.
In practice, the noise is not only due to quantum mottle, but has an anatomic
structural component, and for lung tissue, for which the number of photons in
the image is higher, the anatomic noise may predominate [18]. Superimposition
of a rib degrades the CNR significantly below 80 kVp. The CNR for the heart is
higher above 100 kVp, and for the spine tube potentials of 110 kVp to 120 kVp
or above give the best CNRs. The performance varies between the different
phosphors because the sensitivity of gadolinium oxysulphide increases with
photon energy between 60 kVp and 100 kVp, whereas that for barium fluorohalide
declines (Figures 2 and 3). Both high and low kV techniques have been used for
chest radiography. Higher kV techniques are now generally preferred, as in
addition to the CNR in higher density structures, the greater penetration gives
a smaller range of beam intensities transmitted through the patient, allowing
details to be portrayed in all parts of the image within a narrower exposure
range. Figures of merit derived from equation (10) for different parts of a
chest image, which take account of image quality and dose, are shown in Figure
8. The conditions in which the figure of merit is higher should represent
better imaging performance. Values for the CR phosphor (Figure 8b) are lower,
because of the higher dose level required.
Filtration
Copper filters will absorb a higher proportion, than
aluminium, of the photons with energies between 20 and 50 keV, which make a
significant contribution to patient ESD (Figure 9). An indication of how the
incident air kerma and so the ESD will vary for a radiograph of the abdomen
with different aluminium and copper tube filtration options is shown in Figure
10. With tube potentials of 70-80 kV, reductions of over 50% in ESD and 40% in
effective dose can be achieved by using a 0.2 mm thick copper filter.
The disadvantage of using additional filters is that the
tube output must be increased in order to compensate for the reduction in
photon fluence resulting from attenuation by the extra filters. The tube
output would need to be increased by about 50% at 80 kVp to provide the
necessary air kerma level to compensate for a filter of 0.2 mm of copper. This
may have an impact on the X-ray tube lifetime and also possibly on exposure
times. However, copper is much more efficient at removing lower energy photons
than the addition of more aluminium. A similar reduction in ESD to that given
by the 0.2 mm of copper could only be achieved through the use of 10 mm of
aluminium and this would require the tube output to be almost doubled. Thus,
copper provides a more effective method for increasing filtration than
insertion of more aluminium. The increases in mAs that will be required to
achieve the same density level for a rare earth screen/film combination are
shown for copper filters of different thickness in Figure 11. The reduction in
the proportion of low-energy photons will affect the CNR although the effect is
not large and the relative values of CNR for radiographs obtained with and
without inclusion of an additional 0.2 mm of copper are shown for abdominal radiographs
in Figure 12. For digital radiography, which does not have the limitation in
dynamic range imposed by film systems, the mAs could be increased further to
achieve a similar CNR. Increases in mAs that would be needed in order to
achieve this are also plotted in Figure 11. The corresponding reductions that
could be achieved in incident air kerma or dose-area product through inclusion
of copper filters of varying thickness are shown in Figure 13. The figure also
demonstrates that the most significant reduction is achieved through use of
copper filters of 0.2 mm or less. For screen/film radiography, a similar CNR
with copper could be obtained by reducing the tube potential by about 5 kVp but
this would require a more significant increase in mAs. This approach could be a
viable option for paediatric radiography, where exposure factors are lower.
Here the use of 55 kVp with an additional 0.2 mm of copper could provide a
realistic alternative to a 60 kVp beam.
Discussion and Conclusion
Radiation quality is of particular importance in the
optimisation of radiological imaging in X-ray departments. Variation in
sensitivity of the phosphors used in different systems should be considered in
determining the radiation intensity required. Barium fluorohalide, the predominant
CR phosphor, has a lower energy absorption and so is less sensitive than rare
earth screen phosphors for most diagnostic X-ray beams (Figure 3). However, the
better contrast and dynamic range of digital systems should allow satisfactory
imaging with a CR system employing a similar dose level to that for a 400 speed
index rare earth screen/film combination (2.5 mGy-3.0
mGy at the image plate for 80 kVp). The
sensitivity of caesium iodide flat plate detectors is 50% greater than that for
a rare earth screen/film combination, so that imaging performance equivalent to
a 600 speed index system can be attained (1.6 mGy-2.0
mGy detector dose). Sensitivities of
gadolinium oxysulphide IDR systems are similar to the screen/film equivalent
(400 speed index, 2.5-2.8 mGy detector
dose), although the greater dynamic range may be used to achieve some reduction
in dose. One aspect of performance that can easily be overlooked during the
introduction of digital radiography is the difference in response of the
various phosphors with tube potential. It is important that AEC devices are set
up to take account of the dependence of the phosphor sensitivity on tube
potential at installation, if optimisation is to be achieved. In particular,
the sensitivity of barium fluorohalides used in CR systems is significantly
lower at higher tube potentials, and this is the reverse of the relationship
for rare earth phosphors employed in film cassettes for which sensitivity
increases with tube potential (Figure 3).
For all imaging tasks, the selection of tube potential is
a compromise to achieve the optimum balance between image quality and dose.
High tube potentials are used for thicker parts of the body and adjustments are
made for the weight of the patient in order to avoid patient doses being too
high (Figure 4). Chest imaging presents a particular challenge. High tube
potentials allow all tissues to be imaged within a narrower exposure range,
although contrast within the lung is better at lower tube potentials (Figures 7
and 8). The best compromise is probably 100 kVp to 120 kVp, although 90 kVp to
100 kVp may provide a better option for CR, because of the decline in
sensitivity at higher tube potentials.
Results of the calculations in this study indicate that
incorporation of 0.1 mm or 0.2 mm of copper into most radiological systems will
provide advantages in reducing patient dose (Figures 10 and 13), if the X-ray
tube is capable of giving the additional output required. The tube current
would need to be increased by about 40% to maintain the optical density for
film/screen systems (Figure 11). The broader dynamic range of digital radiology
systems provides more scope for introduction of dose reduction through use of
copper filters, with the facility to increase the exposure to maintain a
similar level for the CNR where this is necessary, or further reduce the dose
level, where the higher level of image quality is not required. Filter options
are now more widely available on new systems and it is important that they are
used and their influence understood.
The growth of digital imaging provides new opportunities
for optimisation. Calculations of CNR of the type described in this paper for
different imaging scenarios can provide the opportunity to evaluate how changes
in radiation quality involving filtration and tube potential are likely to
affect radiological images. They may assist in investigation and assessment of
optimisation strategies prior to their introduction into clinical practice. The
greater availability of digital image data should also provide more
opportunities for analysis and study of image quality, and so facilitate
further optimisation of technique in the future.
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Received 28 November 2006; accepted 12 December 2006
Correspondence: Health Physics, Gartnavel Royal Hospital, Glasgow, G12 OXH, Scotland, United Kingdom. Tel.: +44 0141 211 3387; Fax: +44 0141 211 6761; E-mail: colin.martin@northglasgow.scot.nhs.uk (Colin Martin).
Please cite as: Martin CJ,
The importance of radiation quality for optimisation in radiology, Biomed Imaging Interv J 2007; 3(2):e38
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